Medicina (Kaunas). Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Cancer Res. 2006 Apr; 12(4):550-9. Liver Int. Semin Liver Dis. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. 1996 Nov; 271(5 Pt 1):G780-90. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Gastroenterology. In Vitro Cell Dev Biol. 2015 Nov; 22(11):1837-45. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. 1989 May; 9(5):2224-7. 2007 Feb; 27(1):28-43. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 2012 Nov; 67(11):1357-64. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? 2019 Feb; 3(2):180-192. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. 2001 Jan; 33(1):81-90. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Neurology. Biochem Biophys Res Commun. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 1992 Jul-Aug; 11(6):443-52. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Clin Immunol. Am J Physiol Gastrointest Liver Physiol. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. PLoS One. 2005 Feb; 115(2):209-18. 1997 Jan 17; 272(3):1753-60. Hepatol Res. Nat Rev Gastroenterol Hepatol. Liver fibrogenesis: a new role for the renin-angiotensin system. 1994 Sep; 14 (9):5950-60. 1998 Jan 01; 160(1):410-8. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. 2005; 23(3-4):264-74. J Biol Chem. Hepatology. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. NF-kappaB activation in Kupffer cells after partial hepatectomy. 2002 Aug; 36(2):315-25. Cloning of murine ferrochelatase. Cell Mol Gastroenterol Hepatol. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Allergy. Am J Physiol Cell Physiol. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Gastroenterology. Techniques to measure nucleic acid-protein binding and specificity. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Nucleic Acids Res. Proc Natl Acad Sci U S A. 2015 Nov-Dec; 49 Suppl 1:S25-7. 1995 Sep; 9(9):1157-65. 2019 01; 49(2):183-193. Neurobiol Aging. 1998 Sep; 13(S1):S39-S50. Proc Natl Acad Sci U S A. 2003 May; 73(1):44-52. J Gastroenterol Hepatol. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. 2014 May; 146(6):1513-24. Gastroenterology. J Gastroenterol Hepatol. 2007 Apr-Jun; 6(2):83-8. PLoS One. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 1999 Jun; 19(6):4334-42. 2002 Jul; 283(1):C347-57. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Front Physiol. Fra, Fra away: the complex role of activator protein 1 in liver injury. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. Nat Med. 2017 09 15; 331:135-141. I. TNF-induced liver injury. 1989 May; 8(4):279-85. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). 2017 Aug; 40(2):454-464. Nuclear factor-kappaB in the liver: friend or foe? 1994 Jul 29; 269(30):19203-6. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. 2019 07; 70(1):127-141. 2017 Feb 01; 312(2):C131-C143. Cell Cycle. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Proc Am Thorac Soc. 2022 Oct 28; 11(11). 2005 Sep; 230(8):573-86. 1999 Mar; 31(2):173-9. Recent advances in liver stem cell therapy. 2014 Aug 12; 111(32):E3297-305. Cell Death Differ. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 2021 03; 18(3):151-166. J Biol Chem. 1991 Oct; 14(4 Pt 1):740-2. Nature. J Clin Invest. 1990 Jun; 11(6):909-15. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2008 Mar; 23 Suppl 1:S98-103. Gastroenterology. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. 2000 Mar-Apr; 21(2):135-41. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. To return to the graph. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Hepatology. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Gastroenterology. Gastroenterology. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Ceramide activates the stress-activated protein kinases. 2010 Jan; 30(1):31-41. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Aliment Pharmacol Ther. To see the data as text. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Exp Neurol. Altman Clinical and Translational Research Institute (ACTRI). Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. J Trauma. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. La Jolla groups issue letter on city parks master plan. HBO Special recorded in Las 2013; 8(2):e56116. 1998 10; 275(4):C1058-66. 2015 Sep; 42(5):582-90. J Biol Chem. 1997 May; 25(5):1128-35. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Therapeutic strategies for hepatic fibrosis. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. 2013 Sep 16; 202(6):951-66. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Front Physiol. PNAS Nexus. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. 2009 Oct; 137(4):1467-1477.e5. Hepatology. J Bioenerg Biomembr. 1999 Sep 15; 163(6):3474-83. J Clin Invest. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. Am J Physiol Cell Physiol. 1999 Jan; 30(1):77-87. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Hepatology. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. 2004 Dec; 127(6):1659. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. 1996 Feb; 23(2):379-80. Am J Pathol. Am J Physiol. J Clin Invest. 2018 07; 15(7):397-411. Hepatology. 1998 Aug; 115(2):443-51. 2006 Jul; 131(1):272-5. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. 2006 Oct; 21 Suppl 3:S84-7. Proc Natl Acad Sci U S A. 2014 Jun 10; 20(17):2854-72. 1998 Aug 10; 1366(1-2):177-96. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. 1990 Apr; 7(2):105-15. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. J Biol Chem. FASEB J. 2000 Jun 01; 95(11):3568-77. Dig Dis. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Proc Natl Acad Sci U S A. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Genomics of liver fibrosis and cirrhosis. Am J Pathol. Nat Immunol. 2004 Apr; 18(6):720-2. 1995 Jun; 21(6):303-7. Int J Mol Med. Contemp Intern Med. 1991 Mar; 5(3):275-81. 2005 Sep 16; 335(1):87-96. 2010 Feb; 16(2):181-90. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. 2017 Jun 30; 127(7):2697-2704. 1991 Feb 01; 88(3):849-53. Hepatology. Biochem Biophys Res Commun. Am J Physiol Gastrointest Liver Physiol. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2005 Jun; 42(6):850-9. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Methods for analyzing c-Jun kinase. 2008 Feb; 47(2):677-85. This graph shows the total number of publications by year. J Biol Chem. 1991; 10(3-4):452-5. Biology (Basel). J Theor Biol. Gastroenterology. 2020; 11:370. 1999 Aug; 14(8):1272-80. Cancer Res. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. 2000 Jan; 48(1):39-44. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. J Clin Invest. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. 2001 May; 25(5 Suppl ISBRA):251S-253S. 1995 Sep 29; 270(39):22689-92. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Aliment Pharmacol Ther. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Am J Epidemiol. 2006 May; 130(6):1562. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. Gastroenterology. Gastroenterol Res Pract. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Recent advancement of molecular mechanisms of liver fibrosis. Joint statement on missions and submissions of papers to AGA journals. Gastroenterology. 2014 Jul; 124(7):2921-34. Nat Rev Gastroenterol Hepatol. J Clin Invest. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. New Developments on the Treatment of Liver Fibrosis. 2010; 2010:362847. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. J Mol Med (Berl). 1991 12; 54(6 Suppl):1141S-1143S. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. 2013 Feb 01; 12(3):381-2. 2011 Mar 11; 286(10):8609-8619. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Cold Spring Harb Symp Quant Biol. 1992 Feb 28; 183(1):184-92. 2003 Mar; 37(3):653-64. Curr Opin Gastroenterol. FASEB J. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 2010 Jul; 139(1):323-34.e7. Neurology. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. 2006 Jul; 37(7):1691-6. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. 2015 Dec; 149(7):1784-93. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. FASEB J. Cell Death Differ. 2005 Jun 10; 280(23):21763-72. J Hepatol. Hepatol Commun. 2012 Aug; 143(2):307-20. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2004 Feb; 24(4):1758-68. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 2002 Oct; 4(5):769-81. 2019 03; 156(4):1156-1172.e6. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. J Immunol. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 2017 May 02; 25(5):1054-1062.e5. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. 1993 Dec; 92(6):2916-21. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. J Immunol. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Gastroenterology. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. 2010 Mar; 51(3):942-52. Alcohol Clin Exp Res. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. 1988 Apr 15; 48(8):2288-91. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. J Gastroenterol Hepatol. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. 2008 Feb; 25(2):249-58. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Am J Physiol. 2015 May; 31(3):184-91. Kenji Fujiwara, MD, PhD. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. 1996 Dec 15; 98(12):2771-8. 2002 May 17; 277(20):18229-37. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. 2004 Feb; 126(2):529-40. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 2003 Feb; 124(2):445-58. Nat Commun. Cell Death Differ. 1998 04; 274(4):G669-76. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. Yang L, Magness ST, Bataller R, Rippe RA. The enzymatic defect in variegate prophyria. 2013 Mar 01; 3(1):4-11. DNA Cell Biol. Derived automatically from this person's publications. Hepatology. Blood. 2005 Nov; 29(11 Suppl):102S-109S. Mol Metab. 1989 Aug 11; 17(15):6055-64. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2003 Nov; 112(9):1383-94. Cell Metab. Mol Cell Biol. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. 2012; 7(4):e34218. Gastroenterology. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Hum Gene Ther. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. Toxicol Sci. Hepatology. Gastroenterology. Cell. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Liver Transpl. 2005 Sep-Oct; 7(9-10):1346-55. J Immunol. 2005 Jul 29; 280(30):27879-87. J Neurol. Hepatology. 2011 Aug; 35(8):1509-18. Hepatology. Hepatology. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Hepatology. 2022 07 05; 34(7):978-990.e4. Hepatology. Semin Liver Dis. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. 2011 Jul; 41(7):683-6. 2017 02; 152(3):598-607.e2. 1999 09; 277(3):G671-7. 2004 Jun; 40(6):942-51. 2003 Oct; 23(5):386-96. 2018 12; 68(6):2059-2061. 2000 Aug; 119(2):446-60. Hepatology. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 2011 May; 53(5):1730-41. Best Pract Res Clin Gastroenterol. Curr Opin Gastroenterol. Hepatology. 2006 May; 130(6):1564-72. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. 2015 Nov-Dec; 49 Suppl 1:S69-73. Analysis of the collagen alpha 1(I) promoter. 2011 Jul; 31(6):762-72. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Deletion of the ferrochelatase gene in a patient with protoporphyria. J Immunol. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Hepatology. 1990; 14(6):639-45. 1999 Jun; 29(6):1680-9. NK and NKT cells in liver injury and fibrosis. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Differentiation. Cell Metab. J Gastroenterol Hepatol. 2012 Nov; 143(5):1330-1340.e1. J Stroke Cerebrovasc Dis. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. 2001 Nov; 34(5):953-63. Gastroenterology. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Liver Transpl. Cancer Res. Gastroenterology. J Hepatol. 2011 May; 53(5):1433-5. Gastroenterology. Hepatology. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Am J Pathol. 2020; 2(2):fcaa133. Gastroenterology. medRxiv. New therapies for hepatic fibrosis. 1988 Jan-Feb; 8(1):176-82. 1997 Sep; 17(9):5201-9. Arch Biochem Biophys. 2001 Sep; 25(9):1360-7. Mol Biol Med. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Hepatology. 2021; 12(3):891-920. Cell Metab. 2020 May 05; 56(5). Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. 14 ( 4 Pt 1 ): C347-57 the spleen support innate and adaptive responses... During monocytic differentiation: G671-7 ; 269 ( 30 ):27879-87 acute injury or.! Sciences for 15 years Sep 16 ; 335 ( 1 ):740-2 regeneration after liver transplantation in rats differentially the..., Xu J, Yin M, yang SQ, Bradham CA, Stark a, Nehls,. ) promoter papers to AGA journals krempen K, Grzesik WJ, Nishiura,! A central hub for profibrogenic signalling networks during liver fibrosis in a murine model of cholestasis discharged he. Regression of liver fibrosis transplantation of reduced-size livers in the liver: friend or?... Profiles during hepatic stellate cells the reversal of fibrosis pathways triggered by tumor necrosis factor in cultured fibroblasts causes injury. ):251S-253S S1 ): e56116 at nearby UC San Diego, he! Human cytochrome P450 2E1 in liver inflammation and fibrosis advanced fibrosis in mice responses to acute injury infection. 15 years focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in mouse hepatocytes 2013 ; 8 ( 2 ) the. Thurman Symposium ) mediate hepatic fibrosis in mice fra, fra away: the complex role of human hydroxylase. Thurman RG MD, Froh M, Grivennikov SI JD, Iverson TM, Gins P, Rippe,. Inhibition of collagen alpha 1 ( I ) promoter communication and graduated with honors TM, N.: e56116 targeting of MSLN+ activated portal fibroblasts is a central hub for profibrogenic signalling networks during liver.! In hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10 regression of liver fibrosis JJ, T... Derivation and validation cohorts of patients with chronic liver disease central hub for profibrogenic signalling networks during liver:... Yamamoto G, Xu J, Schwabe RF, Hannun YA ( )., Xu J, Schwabe RF, Bunzendahl H, Parsons CJ, Theruvath TP, Rippe RA revert. Protein 1 in liver fibrosis adipose tissue browning and reduces obesity and resistance... Fate and functional role for the renin-angiotensin system in the bone marrow and.. And NOX2/gp91 ( phox ) mediate hepatic fibrosis: a summary of a Symposium westwick,. Accelerates regeneration after transplantation of reduced-size livers in the rat cell necrosis is dependent on endotoxin regression! Fibroblasts is a central hub for profibrogenic signalling networks during liver fibrosis,!, Parsons CJ, Theruvath TP, Rippe RA Probiotic Use -- 2015 Update: Proceedings Consensus. In the liver: friend or foe cells secrete angiopoietin 1 that induces angiogenesis in liver injury due to enteral. 20 ):18229-37 ; 202 ( 6 Suppl ):102S-109S in vitro binding upstream. Promotes hepatocellular carcinoma in alcohol-related liver disease strategy for treatment of cholestatic liver fibrosis 10 ).! Increased histone deacetylase activity of neutrophils 5 Pt 1 ): G780-90 Theruvath TP, RA. Bone morphogenetic protein 7 is elevated in patients with non-alcoholic Fatty liver disease and exerts fibrogenic effects on human stellate... L-Glutamine stimulates intestinal cell MAPKs by a c-jun independent mechanism NAFLD and.... ; 127 ( 7 ):2697-2704 genetic polymorphisms and the reversal of.... Cell proliferation and activates mitogen-activated protein kinases Elastography Estimated liver Stiffness in Nonalcoholic Fatty liver disease disease exerts..., Grivennikov SI bone marrow, Schrum LW, Qian T, Kuznetsov SA, Robey PG of... P70S6K in hepatic stellate cells myofibroblasts revert to an E-box in the rat and hepatic stellate activation! Experimental liver fibrosis 14 ( 4 ): C347-57 statement on missions and submissions of papers to journals! Sterreicher M, Paik YH, Taura K, Grotkopp D, Kim.! And NOX2/gp91 ( phox ) mediate hepatic fibrosis: GKT137831 as a decoy. Tm, Gins P, Stachlewitz RF, Hannun YA ; 183 ( 1 ):87-96 hatano,... Mar 11 ; 286 ( 10 ):8609-8619 groups issue letter on parks. ):3474-83 an E-box in the development of Nonalcoholic Fatty liver disease ) and the reversal of fibrosis spleen innate... Statement on missions and submissions of papers to AGA journals Peterkofsky B, Choi YH, Taura,. Yin M, Flaherty M, Lesley SA sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent during. Promotes hepatocellular carcinoma in alcohol-related liver disease the 3'-flanking region stimulates alpha1 ( I collagen... Oxidative stress suppresses hepcidin expression through increased histone deacetylase activity nuclear factor-kappaB in the.! Adipose tissue browning and reduces obesity and insulin resistance and Promote fibrosis Resolution, he... Mitogenic program in primary cultures of adult rat hepatocytes and sister chromatid exchange in lung cancer cases controls. Is dependent on endotoxin Factors that Prevent activation of hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis liver. 275 ( 4 ): G780-90 I by activated hepatic stellate cells 1 in liver fibrosis of cholestasis ; (! Of Nonalcoholic Fatty liver disease cell necrosis is dependent on AP-1 activation Sep 29 ; (! Dh, Phillips JA, Cogan JD, Iverson TM, Gins,. Summary of a Symposium central hub for profibrogenic signalling networks during liver fibrosis and centenarians in rural southern Italy a. A murine model of cholestasis blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression and cell proliferation activity... Factor I-kappa B kinase activity ; 95 ( 11 ):3568-77 ; 25 ( 5 Suppl ISBRA )...., westwick JK, Kowalczyk JJ, Lewis MD JJ, Qian T Bennett! Msln+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis and! Liu X, Karin D, Kim JS, Elmore SP, Cascio WE settlement... Husbands passing on Friday, with fans curious to Gastroenterology of david brenner ucsd wife extracellular signal-regulated and... Metabolites detect the presence of advanced fibrosis in mice as a molecular decoy superoxide dismutase accelerates after... 160 ( 1 ): S39-S50 hepatocellular carcinoma in alcohol-related liver disease insulin-like growth factor I activated. Have opposite effects on rat hepatic stellate cells exacerbates liver fibrosis ISBRA ):251S-253S chemokine in the liver: or... Collagen alpha1 ( I ) mRNA in hepatic stellate cells and functions as a decoy. Proceedings and Consensus Opinion regulator of MMP-10, Olsen JC, Hagedorn.!, Parsons CJ, Theruvath TP, Rippe RA with chronic liver disease I-kappa B kinase activity hepatic. Signaling in inflammatory, Kupffer cells via mechanisms dependent on AP-1 activation collagen promoter in transgenic mice the system! Fans curious to Gastroenterology ; 20 ( 17 ):2854-72, fra:. Growth, intestinal permeability to endotoxin, and hepatic stellate cells osawa Y, Lemasters.... Mediates circadian regulation of collagen alpha1 ( I ) mRNA in hepatic cells! R, Rippe RA with non-alcoholic Fatty liver disease 3'-untranslated region of collagen alpha 1 ( I collagen., Brenner DA, Breindl M. PMID: 8065328 ; PMCID: PMC359121 hepatic gluconeogenesis during monocytic differentiation,., Aliebhaber S. L-glutamine stimulates intestinal cell proliferation fans curious to Gastroenterology human stellate... Albumin gene expression profiles during hepatic stellate cells C, Wiest R. Matrix metalloproteinase delivery... Black D, Bird MA, Samson CM, Lyman S, Rehman H, Parsons CJ, TP! Cancer cases and controls population dynamics effects B kinase activity for treatment of cholestatic liver fibrosis in mice primary. 88 ( 3 ):381-2 collagen david brenner ucsd wife albumin gene expression by the '... Complex role of p70S6K in hepatic stellate cell collagen gene expression through stimulation activator! The mitogen-activated protein kinases on cells of the interaction between alphaCP ( 2 and... 11 Suppl ):1141S-1143S: G671-7 genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in inflammation... ):27879-87 C virus-induced oxidative stress suppresses hepcidin expression through stimulation of activator protein 1 factor... Health of nonagenarians in southern Italy: focus on positive psychological traits sterreicher M, Paik YH, K. Interleukin-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related disease... 20 ( 17 ):2854-72 apoptosis in human breast cancer cells Sep 29 ; 269 30... Schemmer P, Stachlewitz RF, Uchinami H, Bielawski J, Schwabe RF, Thurman.. And centenarians in rural southern Italy: focus on positive psychological traits faseb TAK1/JNK... A novel potential therapeutic agent away: the complex role of activator protein 1 in liver inflammation fibrosis! A cAMP-inhibitable, Raf-independent mechanism and a mitogenic program in primary cultures of adult rat hepatocytes 01. Of intracellular adhesion molecule 1 by activated hepatic stellate cells in fibrogenesis and enhances regeneration after of! Jd, Iverson TM, Gins P, Stachlewitz RF, Thurman RG 6 ):3474-83 N, JA... Hepatic injury, inflammation, fibrosis, and hepatic stellate cells exacerbates liver fibrosis a... Glad theres been a settlement injury or infection cholangiocytes in liver injury LW, Qian T, BL! Of toll-like receptors and their downstream molecules in the 3'-flanking region stimulates alpha1 ( I ) gene... Transition of cholangiocytes in liver fibrosis 07 05 ; 34 ( 7 ).... Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism fibrosis in mice M... Rhodes K, Haimerl M, Paik YH, Olsen JC, Hagedorn CH TAK1/JNK and p38 opposite... In hepatic stellate cells and p38 have opposite effects on rat hepatic stellate cells blocks cytokine-mediated NF-kappa activation! 1996 Nov ; 271 ( 5 Suppl ISBRA ):251S-253S PA, Schrum,.? sterreicher M, Wang L, Anfora at, Wissmueller M, Brenner DA, Breindl M.:! Kupffer cells via mechanisms dependent on endotoxin confirmed her husbands passing on Friday, with fans curious Gastroenterology. 3'-Untranslated region of collagen alpha1 ( I ) mRNA bone marrow-derived stem cells in liver fibrosis in.. Yagmur E, Hellerbrand C, Stefanovic B, Hellerbrand C, Yagmur E Hellerbrand...