Exosomal miRNAs have been studied in various cancers as minimally invasive biomarkers. Follow us on @ScimagoJRScimago Lab, Copyright 2007-2022. You are accessing a machine-readable page. ET) or. Conclusion: DVP assessment using OCT-A may be a useful tool for detecting and monitoring OAG eyes with high myopia. Conclusion: Cancer patients in SSA tend to have a relatively lower SARS-CoV-2 seroprevalence compared to potential blood donors recruited from the same geographic locations during the COVID-19 pandemic. published in the various research areas of the journal. Learn about where ACP stands on the following areas: Copyright 2021 American College of Physicians, Inc. All Rights Reserved. A casecontrol study with 774 participants was conducted comparing COVID-19-infected HCWs (cases) and non-infected HCWs (controls) from the Occupational Medicine Unit at the Teaching Hospital Policlinico Umberto I, who were administered the same questionnaire including Hospital Anxiety and Depression Scale, Copenhagen Burnout Inventory and Karaseks Job Content Questionnaire. The results are indicating the need for workplace health promotion activities based on stress and burnout management and prevention. For There was also an association between mild COVID-19 symptoms with prior tuberculosis vaccination among cancer patients. Cardiac computed tomography (CT) has evolved over the past 20 years from an alternative, promising noninvasive imaging modality to a Class I indication for the non-invasive evaluation of patients with low-to-intermediate, pre-test probability of coronary artery disease (CAD), as per the European Society, Cardiac computed tomography (CT) has evolved over the past 20 years from an alternative, promising noninvasive imaging modality to a Class I indication for the non-invasive evaluation of patients with low-to-intermediate, pre-test probability of coronary artery disease (CAD), as per the European Society of Cardiology (ESC) guidelines published in 2019 [], Background: Despite the high COVID-19 morbidity and mortality rates across the world, the reported rates in sub-Saharan Africa (SSA), which has a higher burden of other infectious diseases and overwhelmed healthcare systems, remain relatively low. Patients and Methods: We included patients with type. Make your research data available, accessible, discoverable, and usable. After more than one decade since the introduction of SMILE, only one case report of cataract surgery with IOL implantation after SMILE is present in the peer-reviewed literature. ACP's advertising opportunities enable pharmaceutical and non-pharmaceutical advertisers to place their key messages in front of their targeted physician audiences. Interested in Becoming a Fellow? The aim of this study was to investigate the prognostic value of time from diagnosis to surgery in patients undergoing upfront surgery for primarily resectable pancreatic carcinoma. The best model showed an overall ACC of 81% and 77% on the training and testing data, respectively. Macular ganglion cell-inner plexiform layer thickness (mGCIPLT)cVFS relationships were also investigated as reference standards. 190 North Independence Mall West, Philadelphia, PA 19106-1572 Our aim was to compare the aerobic capacity of vaccinated and unvaccinated individuals previously infected with SARS-CoV-2. Each educational feature focuses on the care of a patient who "falls between the cracks" in available evidence and for whom the optimal clinical management is unclear. To this end, the journal publishes original articles, editorials, reviews, internal medicine flashcards, and other information relevant to internal medicine and related fields. We performed a systematic literature search in 11 databases on 21 May 2022. Surgery for Aortic Prosthetic Valve Endocarditis in the Transcatheter Era, White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder, Cushings syndrome is a rare disease with an endogenous cause of excess cortisol secretion. Editors Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. We also extracted data on the prevalence of pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC), and polypoidal choroidal vasculopathy (PCV). Methods: Twenty-one patients with unilateral or bilateral cochlear implants (Oticon Medical, Purpose: The effect of sarcopenia on the survival of patients with type 2 diabetes remains unclear. High myopia was defined as a spherical equivalent of less than 6.0 diopters or an axial length of 26.0 mm. The relationships between SARS-CoV-2 seroprevalences and study variables were determined using a logistic regression analysis. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. The most recent (2021) Impact Factor forAnnals of Internal Medicineis 51.598 (Clarivate Analytics). If the address matches an existing account you will receive an email with instructions to reset your password. No special There were no differences in baseline demographic and pulmonary function testing (PFT) parameters. Four selected exosomal miRNAs were validated in the plasma of 20 healthy controls (HCs) and 40 ESCC patients via quantitative reverse transcription-polymerase chain reaction. This study aimed to investigate in detail the mechanism. Further evidence indicated that the release of the survival marker IGF-1 was detected in a stem-cell-conditioned medium. Results: High seroprevalence against the SARS-CoV-2 spike and nucleocapsid proteins were found among the SARS-CoV-2 unvaccinated COVID-19 pandemic populations in SSA. prior to publication. The most reported symptoms are fatigue, headache and attention/concentration issues, dyspnea and myalgia. New content every week from the most highly cited internal medicine journal. The most reported symptoms are fatigue, headache and attention/concentration issues, dyspnea and myalgia. Of note, most of the aforementioned inflammatory cytokines utilize the JAK/STAT pathway for downstream signal transduction, explaining the emerging role of JAK inhibitors in the therapeutic armamentarium of AD. To ensure optimal security, this website will soon be unavailable on this browser. A total of 1173 patients who underwent surgery for ASD were identified in the 20172019 NSQIP databases. The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real world cases and situations. The Janus kinase (JAK)/signal transducer and activation of transcription (STAT) pathway constitutes the principal signaling cascade for a large number of cytokines and growth factors and is involved in intracellular signal transduction and subsequent regulation of gene transcription. The Feature Paper can be either an original research article, a substantial novel research study that often involves Cardiovascular Disease in 2021 and beyondWhat Have We Learned and How Do We Move On? We compared individuals unvaccinated at the time of infection to those vaccinated in terms of aerobic capacity, measured using symptom-limited cardiopulmonary exercise test (CPET). This study aims to investigate whether HCWs infected with COVID-19 may experience potential psychological consequences and a higher incidence of depression, anxiety, work-related stress, and burnout compared to non-infected HCWs. In contrast, DVPcVFS correlations were significantly lower than SVPcVFS and mGCILTcVFS correlations in NMG eyes. This Annals' "On Being a Doctor" Story Slam was made possible with generous support from the Josiah Macy Jr. Foundation. Get answers now. The AUROC was 0.84. Significant increases in cell viability and the expression of SOD2, as well as a reduction in oxidative stress and the suppression of p53, were found in D-galactose-stressed H9c2 cells cultured with a stem-cell-conditioned medium, whereas the depletion of IGF-1 in stem-cell-conditioned medium diminished the antiaging effect on H9c2 cells. Billing and coding, accessing financial assistance, payer policies, and other updated guidance. The Janus kinase (JAK)/signal transducer and activation of transcription (STAT) pathway constitutes the. The data were split into 70% training and 30% testing cohorts. Purpose: To investigate the relationship between two distinct layers of macular vessel density (superficial vascular plexus (SVP) and deep vascular plexus (DVP)) and central visual field sensitivity (cVFS) in open-angle glaucoma (OAG) eyes with high myopia. In vitro and in vivo models were designed to explore the above hypothesis. No differences in the levels of burnout and decision latitude were found between the two groups. Cushings syndrome is a rare disease with an endogenous cause of excess cortisol secretion. We use cookies on our website to ensure you get the best experience. Editors select a small number of articles recently published in the journal that they believe will be particularly The Impact Factor is a measurement of the frequency with which the average article has been cited. We conclude that there should be low threshold to recommend ophthalmic examination to patients with Cushings syndrome, and that a macular OCT is recommended during this examination. Please upgrade your browser to improve your experience. Parasomnias are sleep disorders that involve abnormal behaviors, emotional experiences, perceptions, and dream activity, occurring during specific sleep stages or sleepwake transitions. Methods: Plasma samples collected during the COVID-19 pandemic from SARS-CoV-2 unvaccinated cancer and potential blood donor populations were analyzed for SARS-CoV-2 (spike and nucleocapsid proteins) antibodies by an immunofluorescence assay. Small incision lenticule extraction (SMILE), with over 5 million procedures globally performed, will challenge ophthalmologists in the foreseeable future with accurate intraocular lens power calculations in an ageing population. Individual and institutional subscriptions available. Annals publishes a wide variety of original research, review articles, clinical practice guidelines, and commentaries relevant to clinical practice. Feature Original graphic narratives on medically relevant topics. We extracted data on subfoveal choroidal thickness in patients with Cushings syndrome compared to matched controls. Its content not only advances the science of medicine, but educates and entertains readers through a variety of features, such as: Read the journal in print or on any device. They address medically relevant topicsbe they poignant, thought-provoking, or just plain entertaining. Cases showed higher level of anxiety and job demand compared to controls. Such situations include those in which a guideline finds evidence insufficient to make a recommendation, a patient does not fit criteria mapped out in recommendations, or different organizations provide conflicting recommendations. Please note that many of the page functionalities won't work as expected without javascript enabled. Of the differentially expressed 14 miRNAs, the top 2 up-regulated miRNAs (miR-205-5p and miR-429) and top 2 down-regulated miRNAs (miR-375-3p and miR-483-3p) were selected as ESCC target miRNAs. Enter your email address below and we will send you the reset instructions. Series 2, Data evaluation and methods research, Journal of the American Society of Nephrology : JASN. The model was assessed by its sensitivity, positive predictive value, F1-score, accuracy (ACC), and area under the curve (AUROC). Studies were considered eligible if they performed retinal examination of a consecutive group of patients with Cushings syndrome using optical coherence tomography (OCT) scans. Results: We recruited 28 unvaccinated and 22 vaccinated patients. More evidence substantially links cortisol levels to the pachychoroid spectrum diseases. This type of Doctors share brief stories with an audience in video form, building on the popular Annals feature "On Being a Doctor.". Our mission is to promote excellence in medicine, enable physicians and other health care professionals to be well-informed members of the medical community and society, advance standards in the conduct and reporting of medical research, and contribute to improving the health of people worldwide. According to both univariate and multivariate Cox regression analyses, the adjusted hazard ratios (aHRs; 95% confidence interval [CI]) of all-cause death for the sarcopenia diabetes group compared with the control group: 1.35 (1.331.38; Multicentric carpo-tarsal osteolysis (MCTO) is a rare osteolysis syndrome mainly involving carpal and tarsal bones usually presenting in early childhood. The co-culture of D-galactose-stressed H9c2 with mesenchymal stem cells significantly improved the above pathological signaling. The use of artificial neural networks (ANNs) offers the potential for high predictive capability. The Consult Guys videos, starring Geno J. Merli, MD, FACP, FHM, FSVM, and Howard H. Weitz, MD, FACP, FACC, are available to everyone, and ACP Members and Annals subscribers can earn CME for each video. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. Method: This retrospective cross-sectional study included 148 OAG eyes (64 highly myopic (HMG) and 84 non-highly myopic glaucomas (NMG)) as well as 54 healthy eyes. Patients and Methods: We included patients with type 2 diabetes and categorized them into two groups according to whether they had sarcopenia and compared their survival; patients in the groups were matched at a ratio of 1:2. (1) Background: Delay in therapy for pancreatic ductal adenocarcinoma (PDAC) may contribute to a worse outcome. Story Slams are events that celebrate storytelling by providing an opportunity for participants to verbally share brief stories with an audience. The transfusion rate was 50.0% (586/1173 patients). Therefore, we designed a propensity score-matched population-based cohort study to compare the patients with diabetes with or without sarcopenia. Continue the tradition of Fellowship by sharing your own experience and offering to support other members' candidacies. Access Elseviers most recent Global Gender Report. Sponsor a Fellow You seem to have javascript disabled. Please upgrade your browser to allow continued use of ACP websites. The use of artificial neural networks (ANNs) offers the potential for high predictive capability. Electronic delivery of journal content, exactly how you want it. We identified six eligible studies with a total of 159 patients with Cushings syndrome. This study aimed to investigate the potential of exosomal microRNAs (miRNAs) as biomarkers for esophageal squamous cell carcinoma (ESCC). This study aims to better understand the potential factors that contribute to this phenomenon, especially among cancer patients who are considered as a high-risk group for developing severe COVID-19. permission provided that the original article is clearly cited. Eighteen patient and operative variables were used. Visit the Annals websitefor exclusive features not found in the print editions, including: Grand Rounds discussions including video, slides, CME/MOC that address vexing clinical issues using a real patient's case. After more than one decade since the introduction of SMILE, only one case report. 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All Rights Reserved. Analyzed parameters included patients demographics, clinical presentation, diagnostic work-up, perioperative data and repair durability during follow-up. Hence, the scope of the present multicenter study was to compare the IOL power calculation accuracy in post-SMILE eyes between ray tracing and a range of empirically optimized formulae available in the ASCRS post-keratorefractive surgery IOL power online calculator. Pachychoroid spectrum diseases were relatively common in these patients: PPE in 20.8%, CSC in 7.7%, and PCV in 2.8%. Method: This retrospective cross-sectional study included 148. Hundreds of curated CME and MOC activities that match your interests and meet your needs for modular education, many free to members. 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The expression of plasma exosomal miR-205-5p and miR-429 significantly increased, while that of plasma exosomal miR-375-3p was significantly reduced in ESCC patients compared to that in HCs. In contrast, levels of depression in the case group were significantly lower compared to the control group. In this systematic review and meta-analysis, we summarize available evidence on pachychoroid spectrum diseases in patients with Cushings syndrome. Small incision lenticule extraction (SMILE), with over 5 million procedures globally performed, will challenge ophthalmologists in the foreseeable future with accurate intraocular lens power calculations in an ageing population. In this systematic review and meta-analysis, we summarize available evidence on pachychoroid spectrum diseases in patients with Cushings. However, the cancer patients demonstrated a lower seroprevalence compared to potential blood donors. several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest interesting to authors, or important in this field. Exosomes were isolated from cultures of esophageal epithelial cell and ESCC cell lines using ExoDisc, and exosomal miRNAs were detected via miRNA sequencing. Results: DVPcVFS correlations were as strong as those for SVPcVFS and mGCIPLTcVFS in HMG eyes. Treating a patient? The outcome variable was receiving RBC transfusion intraoperatively or within 72 h after surgery. In addition, reduced aerobic capacity has been demonstrated in both, Patients previously infected with acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may experience post-acute adverse health outcomes, known as long COVID. Clinical experts provide opinions and comment on how they would approach the patient's care. Average time between the initial procedure and detection of the aortoenteric fistula was 69.4 72.5 months. quality clinical studies related to internal medicine; papers defining the unmet clinical needs in several areas of internal medicine; methodology of clinical research and critical reading of clinical studies; high-level subgroup or secondary analyses of the major clinical trials; experimental design of planned or ongoing large clinical trials.