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Blanco, Blanco J. and Balleste, Torralba J. Nanotechnology. Shrivastava, S., Singh, S. K., Mukhopadhyay, A., Sinha, A. S., Mandal, R. K., and Dash, D. Negative regulation of fibrin polymerization and clot formation by nanoparticles of silver. 2011;119(1):37-44. Vermeulen, H., van Hattem, J. M., Storm-Versloot, M. N., and Ubbink, D. T. Topical silver for treating infected wounds. View abstract. Klotter J. View abstract. Comparison of the ionic silver-containing hydrofiber and paraffin gauze dressing on split-thickness skin graft donor sites. 9-1-2010;79(2):340-344. Journal of Applied Sciences 2010;10(1):65-70. A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds. 2008 Biatain First Prize. View abstract. View abstract. Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. A., and Mangalagiu, I. I. Inorg.Chem. Fumal, I., Braham, C., Paquet, P., Pierard-Franchimont, C., and Pierard, G. E. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Galiano, K., Pleifer, C., Engelhardt, K., Brossner, G., Lackner, P., Huck, C., Lass-Florl, C., and Obwegeser, A. J Wound Care 2005;14(9):411-419. Environ Sci Technol. Nanoscale. View abstract. B., Berceli, S. A., Nelson, P. R., Lee, W. A., and Ozaki, C. K. Impact of an absorbent silver-eluting dressing system on lower extremity revascularization wound complications. Jain, J., Arora, S., Rajwade, J. M., Omray, P., Khandelwal, S., and Paknikar, K. M. Silver nanoparticles in therapeutics: development of an antimicrobial gel formulation for topical use. Sung, J. H., Ji, J. H., Song, K. S., Lee, J. H., Choi, K. H., Lee, S. H., and Yu, I. J. Hinyokika Kiyo 1997;43(1):19-23. Nanomedicine. Jurczak, F., Dugre, T., Johnstone, A., Offori, T., Vujovic, Z., and Hollander, D. Randomised clinical trial of Hydrofiber dressing with silver versus povidone-iodine gauze in the management of open surgical and traumatic wounds. Anal Bioanal.Chem. 9-13-2010;11(9):2366-2375. View abstract. Anaesthesia 1988;43(9):755-756. View abstract. Langmuir 3-4-2008;24(5):2051-2056. Environ Health Perspect. Lett Appl Microbiol. View abstract. Acta Clin Belg. B., Ramirez, J. T., and Yacaman, M. J. View abstract. Online retailers market colloidal silver as a cure-all for cancer and other health problems, but theres no scientific evidence to back up the claims. Lok, C. N., Ho, C. M., Chen, R., He, Q. Y., Yu, W. Y., Sun, H., Tam, P. K., Chiu, J. F., and Che, C. M. Silver nanoparticles: partial oxidation and antibacterial activities. View abstract. Panacek, A., Kvitek, L., Prucek, R., Kolar, M., Vecerova, R., Pizurova, N., Sharma, V. K., Nevecna, T., and Zboril, R. Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity. A., Knetsch, M. L., Aldenhoff, Y. Eby, D. M., Schaeublin, N. M., Farrington, K. E., Hussain, S. M., and Johnson, G. R. Lysozyme catalyzes the formation of antimicrobial silver nanoparticles. Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish. Lapied, E., Moudilou, E., Exbrayat, J. M., Oughton, D. H., and Joner, E. J. FDA Talk Paper, Aug 17, 1999. Colloidal silver might decrease how much penicillamine your body absorbs. Mehrbod, P., Motamed, N., Tabatabaian, M., Soleimani Estyar, R., Amini, E., Shahidi, M., and Kheiri, M. T. In vitro antiviral effect of "nanosilver" on influenza virus. 2010;32(3):391-397. 10-15-2010;100(2):160-167. View abstract. View abstract. Cavanagh, M. H., Burrell, R. E., and Nadworny, P. L. Evaluating antimicrobial efficacy of new commercially available silver dressings. 2010;60(7):770-781. View abstract. Paulo, C. S., Vidal, M., and Ferreira, L. S. Antifungal nanoparticles and surfaces. Macromol.Biosci. Kim, K. J., Sung, W. S., Moon, S. K., Choi, J. S., Kim, J. G., and Lee, D. G. Antifungal effect of silver nanoparticles on dermatophytes. Wei, D., Sun, W., Qian, W., Ye, Y., and Ma, X. But does it actually work? Burns 2001;27(1):67-74. Hinyokika Kiyo 1993;39(3):293-298. Skin Pharmacol Physiol 2006;19(3):140-146. The disruption of bacterial membrane integrity through ROS generation induced by nanohybrids of silver and clay. Journal of the American Academy of Dermatology 2005;52:21. View abstract. View abstract. View abstract. Drug Metab Dispos. Li, T., Albee, B., Alemayehu, M., Diaz, R., Ingham, L., Kamal, S., Rodriguez, M., and Bishnoi, S. W. Comparative toxicity study of Ag, Au, and Ag-Au bimetallic nanoparticles on Daphnia magna. View abstract. Its unknown exactly how colloidal silver works. Jacobs, A. M. and Tomczak, R. Evaluation of Bensal HP for the treatment of diabetic foot ulcers. This might decrease the effects of penicillamine. Colloidal silver might decrease how much levothyroxine the body absorbs. Mar.Environ Res 2010;69 Suppl:S49-S51. View abstract. ACS Appl Mater.Interfaces. View abstract. View abstract. Since then, the FDA has not approved any new colloidal silver drugs on the market. Environ Toxicol.Chem. Sur, I., Cam, D., Kahraman, M., Baysal, A., and Culha, M. Interaction of multi-functional silver nanoparticles with living cells. View abstract. Injury 2010;41(5):522-527. 1950;6(3):173-176. Graefes Arch Clin Exp.Ophthalmol. View abstract. J Exp.Med 2-28-1931;53(3):413-420. View abstract. Development of silver-zein composites as a promising antimicrobial agent. View abstract. This article explains what colloidal silver is, then details its uses, health claims, and risks. 2010;54(10):4208-4218. Youre environmentally exposed to extremely small amounts of silver every day. Bryaskova, R., Pencheva, D., Kyulavska, M., Bozukova, D., Debuigne, A., and Detrembleur, C. Antibacterial activity of poly(vinyl alcohol)-b-poly(acrylonitrile) based micelles loaded with silver nanoparticles. Sung, J. H., Ji, J. H., Park, J. D., Yoon, J. U., Kim, D. S., Jeon, K. S., Song, M. Y., Jeong, J., Han, B. S., Han, J. H., Chung, Y. H., Chang, H. K., Lee, J. H., Cho, M. H., Kelman, B. J., and Yu, I. J. Subchronic inhalation toxicity of silver nanoparticles. Yang, W., Lee, S., Lee, J., Bae, Y., and Kim, D. Silver nanoparticle-induced degranulation observed with quantitative phase microscopy. Otherwise, the product is considered misbranded and is subject to regulatory action (3). This article examines its history, purported benefits, and recommended dosage. Kong, H. and Jang, J. Synthesis and antimicrobial properties of novel silver/polyrhodanine nanofibers. Boone, D., Braitman, E., and Gentics, C. Bacterial burden and wound outcomes as influenced by negative pressure wound therapy. Int Wound J 2005;2(1):64-73. View abstract. Chun, J. Y., Kang, H. K., Jeong, L., Kang, Y. O., Oh, J. E., Yeo, I. S., Jung, S. Y., Park, W. H., and Min, B. M. Epidermal cellular response to poly(vinyl alcohol) nanofibers containing silver nanoparticles. Colloids Surf.B Biointerfaces. American Biology Teacher 2009;71(4):231-234. Russell, L. The CONTOP multinational study: preliminary data from the UK arm. View abstract. This allows silver ions to pass into bacterial cells, where they interfere with metabolic processes and damage DNA, leading to the cells death (8, 9, 10). View abstract. However, its thought that it binds to bacterial cells and damages their cell walls and DNA, resulting in cell death. It can also stimulate melanin production in skin, and areas exposed to the sun will become increasingly discolored. 2010;15(4):045005. 2009;7:8. Colloidal silver might harm the liver. Biotechnol.Lett 2008;30(11):1893-1899. View abstract. View abstract. View abstract. Hyun, J. S., Lee, B. S., Ryu, H. Y., Sung, J. H., Chung, K. H., and Yu, I. J. View abstract. Jude, E. B., Apelqvist, J., Spraul, M., and Martini, J. J Nanobiotechnology. 3-1-2010;76(1):32-37. Cochrane Database.Syst.Rev 2007;(1):CD005486. There are currently no FDA-approved over-the-counter or prescription drugs containing silver that are taken by mouth. J Toxicol.Environ Health A 2009;72(21-22):1279-1284. View abstract. Yoon, K. Y., Hoon, Byeon J., Park, J. H., and Hwang, J. Susceptibility constants of Escherichia coli and Bacillus subtilis to silver and copper nanoparticles. Elliott, C. The effects of silver dressings on chronic and burns wound healing. 2009;48(2):173-179. View abstract. View abstract. Nanotoxicology. In many cases, these products are sold as dietary supplements and make false, misleading health claims (12). Chae, Y. J., Pham, C. H., Lee, J., Bae, E., Yi, J., and Gu, M. B. 2010;5:337-342. Rattanaruengsrikul, V., Pimpha, N., and Supaphol, P. Development of gelatin hydrogel pads as antibacterial wound dressings. View abstract. Lansdown, A. B., van der Veen, F. H., Maessen, J. G., Stobberingh, E. E., and Koole, L. H. The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood. J Wound Care 2003;12(3):101-107. Sheikpranbabu, S., Kalishwaralal, K., Venkataraman, D., Eom, S. H., Park, J., and Gurunathan, S. Silver nanoparticles inhibit VEGF-and IL-1beta-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells. Muangman, P., Pundee, C., Opasanon, S., and Muangman, S. A prospective, randomized trial of silver containing hydrofiber dressing versus 1% silver sulfadiazine for the treatment of partial thickness burns. View abstract. J Nanobiotechnology. 2010;76(4):1082-1087. Lazareth, I., Ourabah, Z., Senet, P., Cartier, H., Sauvadet, A., and Bohbot, S. Evaluation of a new silver foam dressing in patients with critically colonised venous leg ulcers. Sap-Iam, N., Homklinchan, C., and Larpudomlert, R. UV Irradiation-induced Silver Nanoparticles as Mosquito Larvicides. Sci Total Environ 11-1-2010;408(23):5817-5823. J Phys Chem.B 8-24-2006;110(33):16248-16253. Chang, A. L., Khosravi, V., and Egbert, B. 11-11-2009;20(45):455104. If you use silver frequently on an open wound, you may experience localized argyria due to a buildup of silver in the surrounding tissue though this condition is rare (18). Int J Antimicrob.Agents 2004;23 Suppl 1:S75-S78. 2010;6(2):192-197. View abstract. 5-28-2010;21(21):215102. View abstract. Antimicrob.Agents Chemother. Penicillamine is used for Wilson's disease and rheumatoid arthritis. J Nanobiotechnology. B. Acad.Emerg.Med 1995;2(1):4-10. 2007;73(6):1712-1720. Silver(I)-imidazole cyclophane gem-diol complexes encapsulated by electrospun tecophilic nanofibers: formation of nanosilver particles and antimicrobial activity. Here is a list of 4 natural supplements that are just as effective as pharmaceutical drugs. Colloidal silver is a popular remedy in alternative medicine. Chen, Z., Xie, S., Shen, L., Du, Y., He, S., Li, Q., Liang, Z., Meng, X., Li, B., Xu, X., Ma, H., Huang, Y., and Shao, Y. 2010;8:1. Have you ever wondered if herbs like Japanese knotweed are as healthy as advertised? View abstract. Bilberg, K., Malte, H., Wang, T., and Baatrup, E. Silver nanoparticles and silver nitrate cause respiratory stress in Eurasian perch (Perca fluviatilis). Jain, P. and Pradeep, T. Potential of silver nanoparticle-coated polyurethane foam as an antibacterial water filter. [Preparation and antibacterial capacity of artificial skin loaded with nanoparticles silver using bacterial cellulose]. Kim, J., Kwon, S., and Ostler, E. Antimicrobial effect of silver-impregnated cellulose: potential for antimicrobial therapy. View abstract. 12-1-2008;42(23):8617. 1-31-2010;96(2):159-165. Sci Total Environ 9-15-2009;407(19):5243-5246. Carlson, C., Hussain, S. M., Schrand, A. M., Braydich-Stolle, L. K., Hess, K. L., Jones, R. L., and Schlager, J. J. Muangman, P., Chuntrasakul, C., Silthram, S., Suvanchote, S., Benjathanung, R., Kittidacha, S., and Rueksomtawin, S. Comparison of efficacy of 1% silver sulfadiazine and Acticoat for treatment of partial-thickness burn wounds. J Colloid Interface Sci 4-15-2010;344(2):424-428. Clin.Exp.Dermatol. Fung MC, Weintraub M, Bowen DL. Small 2009;5(13):1553-1561. View abstract. 2006;25(7):1809-1816. Reducing the Toxicity of Antimicrobial Silver. 8-31-2010; View abstract. Finally, silver is found in other commercial products, such as cleaning agents, agricultural treatments, and personal hygiene products like shower gels and deodorants (7). Arch.Ophthalmol. FDA issues final rule on OTC drug products containing colloidal silver. View abstract. Nanotoxicology. Wise, J. P., Sr., Goodale, B. C., Wise, S. S., Craig, G. A., Pongan, A. F., Walter, R. B., Thompson, W. D., Ng, A. K., Aboueissa, A. M., Mitani, H., Spalding, M. J., and Mason, M. D. Silver nanospheres are cytotoxic and genotoxic to fish cells. J Antimicrob.Chemother. Environ Health Perspect. View abstract. Efficacy of ionic silver dressing and gel in local treatment of dog bite III wounds: a randomized control study. Ann Vasc.Surg 2007;21(5):598-602. Homeopathy is based on the premise that very low doses of a substance can produce health benefits, though little research supports this (7). 3-1-2010;76(1):50-56. Akhavan, O. J Air Waste Manag.Assoc. 3rd European Conference on Advances in Wound Management; 19-22 October; Harrogate, UK. However, research suggests that it attaches to proteins on the cell walls of bacteria, damaging their cell membranes (8, 9, 10). Argyria associated with colloidal silver supplementation. A., Roos, N., Hassellov, M., Tollefsen, K. E., and Thomas, K. V. Uptake and effects of manufactured silver nanoparticles in rainbow trout (Oncorhynchus mykiss) gill cells. 11-1-2010;81(1):358-362. Environ Sci Technol. View abstract. 2010;8:19. Suresh, A. K., Pelletier, D. A., Wang, W., Moon, J. W., Gu, B., Mortensen, N. P., Allison, D. P., Joy, D. C., Phelps, T. J., and Doktycz, M. J. This can lead to an irreversible bluish skin discoloration that first appears in the gums. Med Eng Phys 2008;30(8):948-952. Choi, O., Clevenger, T. E., Deng, B., Surampalli, R. Y., Ross, L., Jr., and Hu, Z. Oral colloidal silver and argyria are out: safe dressings are in. Silver ions are released from the silver particles when they come into contact with moisture, such as body fluids. View abstract. Stevens, K. N., Crespo-Biel, O., van den Bosch, E. E., Dias, A. Beele, H., Meuleneire, F., Nahuys, M., and Percival, S. L. A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing. Sawosz, E., Binek, M., Grodzik, M., Zielinska, M., Sysa, P., Szmidt, M., Niemiec, T., and Chwalibog, A. Chemical Engineering Progress 2010;106(4):11-12. J Hosp.Infect. View abstract. 2007;19(10):857-871. 2008;18(1):176-182. Krishnaraj, C., Jagan, E. G., Rajasekar, S., Selvakumar, P., Kalaichelvan, P. T., and Mohan, N. Synthesis of silver nanoparticles using Acalypha indica leaf extracts and its antibacterial activity against water borne pathogens. 11-1-2010;44(21):8337-8342. View abstract. View abstract. Chadwick, P., Taherinejad, F., Hamberg, K., and Waring, M. Clinical and scientific data on a silver-containing soft-silicone foam dressing: an overview. 10-28-2010; View abstract. Gulbranson SH, Hud JA, Hansen RC. Nanotechnology. View abstract. 2010;4:186-195. View abstract. Santoro, C. M., Duchsherer, N. L., and Grainger, D. W. Antimicrobial efficacy and ocular cell toxicity from silver nanoparticles. Biotechnol.Bioeng. Kim, W. Y., Kim, J., Park, J. D., Ryu, H. Y., and Yu, I. J. Histological study of gender differences in accumulation of silver nanoparticles in kidneys of Fischer 344 rats. Lok, C. N., Ho, C. M., Chen, R., He, Q. Y., Yu, W. Y., Sun, H., Tam, P. K., Chiu, J. F., and Che, C. M. Proteomic analysis of the mode of antibacterial action of silver nanoparticles. However, this product is still commonly sold as a dietary supplement (1, 2). University of Washington. Orthopade 2004;33(8):885-892. Further, no human data supports consuming colloidal silver to treat or prevent medical conditions like diabetes, cancer, HIV, digestive issues, and other illnesses (8). Greulich, C., Diendorf, J., Simon, T., Eggeler, G., Epple, M., and Koller, M. Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells. 2010;27(4):875-881.